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From a reproductive perspective, the currently available evidence is concentrated mainly on the natural conception pathway and is most consistent with the possibility that metabolic optimization may improve the conception window and shorten time to pregnancy (TTP) in selected women with PCOS

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Missaglia, S., Coleman, R., Mordente, A

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Many important mediators, such as IL-1 and TNF-, recruit death-inducing signaling complexes via binding with respective ligands, and subsequently activate the caspase signaling pathway, ultimately leading to internucleosomal DNA fragmentation 31,32