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We also thank the Comparative Medicine Branch of National Institute of Environmental Health Sciences for support with animal experiments and Drs

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Significant shifts in microbiota family composition caused by the antimicrobial in both groups that included decreases in the proportion of Lachnospiraceae , Coriobacteriaceae and unidentified Clostridiales

Herein it is hypothesized that excessive intake of folic acid depletes serum holotranscobalamin, thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues