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While muscle loss is standard with any diet or weight-loss regimen, loss of muscle on GLP-1s can be more dramatic, Ahmed says, causing what's been dubbed "Ozempic face," a bonier, looser-skinned look, where the muscle loss is particularly noticeable

There's also worry about GLP-1 medications causing thyroid cancer, and 2022 study 29 shows an increasing trend between certain cancers and GLP-1 drug users

European Clinical Trials Database (EudraCT)

3) Resting heart rate - my resting heart rate did creep up from roughly 44 to about 50

Scientists developed it as a triple hormone receptor agonist , meaning it activates three different metabolic pathways in the body