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They suppress appetite through hypothalamic signaling, enhance insulin sensitivity, reduce glucagon secretion, and slow gastric emptying

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Salam MA, Al-Amin MY, Salam MT, et al

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10.1038/s41588-022-01034-x 133 PanX.-W.ZhangH.XuD.ChenJ.-X.ChenW.-J.GanS.-S.et al (2020)

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But unlike natural GLP-1, which decays very rapidly (its half-life is just 2 minutes), synthetic GLP-1 receptor agonists are long-acting and remain active in your body for hours or days

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