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Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity

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The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver