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Studies have shown that 1,25(OH)D enhances intercellular adhesion among keratinocytes by upregulating E-cadherin expression and inhibiting -catenin nuclear translocation, thereby stabilizing adherens junction complexes and reinforcing the integrity of tight junctions in the epidermis [222]

To contextualize exposure-response, researchers chart time-aligned changes in glucose excursions, lipid oxidation, and respiratory quotient, often with crossover or factorial designs to reduce variance