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For instance, in the central nervous system, dopamine may prioritize protecting dopaminergic neurons from ferroptosis, whereas its mechanisms in peripheral tissues, such as the gut, may differ (174)
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Stem Cells Transl Med
Therefore, therapeutic strategies that target the distinct mitochondrial metabolic features of CSCs and DTPs, such as disrupting the AMPKOXPHOS axis, inhibiting mitophagy, or decoupling metabolic signaling from DNA repair, represent a promising approach to overcoming chemoresistance in CRC
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