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These data suggested that gut microbiotamediated PAR2 activation, which is attenuated in PAR2-R38E mice (21, 22), contributed to the alteration in postprandial homeostatic GLP-1 levels

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For context, heres how the most recent GLP-1 weight-loss drugs reached UK patients: Wegovy (semaglutide 2.4 mg): MHRA approval September 2021, NICE TA875 issued March 2023

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Insights into the early use of oral semaglutide in routine clinical practice: the IGNITE study

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