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This direction of effect aligns with the pathophysiological hypothesis linking oxidative stress to AMS symptom development (e.g., endothelial dysfunction, increase permeability) and the potential benefit of strategies that modulate ROS production or enhance endogenous antioxidant capacity ( An additional consideration is the methodological quality of the included trials

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Treating type 2 diabetes with metformin Lifestyle interventions encompassing healthy eating and physical activity recommendations need to be provided to children with T2D in a culturally and developmentally appropriate manner (96)

Genetic context does not predict exact treatment response, but understanding your genetic predispositions in these pathways can help frame expectations and guide dose strategy

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