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However, factors such as aging, poor diet, stress, and environmental toxins can deplete glutathione levels, leading to oxidative stress and accelerated aging
S.TiffanyC.JonesR.TheisenB.et al (2018)
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Since the time course of the changes in ERK1/2 activity generally correlate with the development of morphine tolerance, it has been assumed (perhaps prematurely) that ERK1/2 activation plays a role in morphine tolerance
The copper-dependent mechanisms add antioxidant protection that prevents ROS-driven collagen degradation concurrently with stimulating synthesis
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