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Tirzepatide, for example, is a dual GIP/GLP-1 receptor agonist that activates two distinct metabolic pathways, potentially offering different clinical responses across patient populations

Am J Clin Nutr 90:161522 Han SG, Han SS, Toborek M, Hennig B (2012) EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

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Safety Monitoring Recommendations Based on the available clinical trial data, clinicians prescribing orforglipron should: (1) counsel patients about expected GI side effects during dose escalation, (2) follow the recommended dose-titration schedule to minimize GI intolerance, (3) monitor for signs of pancreatitis and discontinue if suspected, (4) assess hepatic and renal function at baseline and periodically, (5) screen for personal or family history of MTC or MEN 2, and (6) review concomitant medications for potential CYP3A-mediated drug interactions

With other supplements, a slight increase in glutathione (GSH) could only be observed after many months of daily supplementation