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In such cases, up-regulation of the plasma membrane redox system may help maintain an adequate pool of NAD+ to fuel the increased glycolysis needed to maintain cell viability in the absence of mitochondrial activity

While previous investigations have primarily relied on fMRI to assess neural activity and FC, quantitative MRS and DTI had not yet been employed in this model

It is supplied for research use only, not for human or veterinary consumption

The results come just a few weeks after a once-weekly injectable GLP-1 drug CT-388 also sourced from Carmot achieved an average weight loss of 18.8% at 24 weeks in a phase 1b trial, which the company said pointed to a potential "best-in-class" profile

doi: 10.1021/acs.molpharmaceut.9b00788