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Do not exceed recommended dosage

Aside from serotonin, tryptophan is catabolized into several other neuroactive compounds, including the neurotoxic kynurenine (KYN) and the neuroprotective kynurenic acid (KYNA) (Figure 3)

Upon DNA damage, p53 is activated to induce cell cycle arrest, thereby providing the cell with sufficient time, resources, and energy to repair damaged DNA

The most prescribed pre-index diabetes medications include metformin (75.1%), GLP-1 RAs (excluding OW sema T2D, 54.3%), and insulin (53.5%) ( Figure 2 )

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