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Over-expression of a rice tau class glutathione S-transferase gene improves tolerance to salinity and oxidative stresses in Arabidopsis

What NAPQI does: Directly binds to and damages cellular proteins Depletes glutathione rapidly Generates oxidative stress which damages DNA Triggers cell death Damages mitochondria, disrupting energy production NAPQI crosses the placenta and depletes fetal brain glutathione at doses below those causing maternal liver toxicity

Dose-response for any indication, all proposed protocols are extrapolated from animal studies

[PMC free article: PMC4500284] [PubMed: 26100900] ABSTRACT INTRODUCTION TARGETS OF PHARMACOTHERAPY IN THE MANAGEMENT OF OBESITY CENTRALLY-ACTING ANTI-OBESITY DRUGS GASTROINTESTINAL AND PANCREATIC PEPTIDES THAT REGULATE FOOD INTAKE PERIPHERAL MODULATORS OF THE EFFICIENCY OF DIGESTION, METABOLISM, AND LIPOGENESIS ALTERNATIVE AND COMPLEMENTARY TYPES OF TREATMENT OF OBESITY CONCLUSION REFERENCES Review Pharmacologic Treatment of Overweight and Obesity in Adults.[Endotext

doi: 10.1080/21645515.2022.2066425 106 RodriguezJAMBifanoMRoca GomaEet al