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Progressive overload, meaning gradual increases in weight, reps, or volume, provides the mechanical signal required to preserve muscle during GLP-1-related caloric deficit

GLP-1 injections like semaglutide and tirzepatide

Roughly one in eight US adults have taken the GLP-1 drugs, but Goldman Sachs estimates that 10 million to 70 million US consumers could be taking them in the next four years

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Drug Interactions Between GLP-1s and Bupropion Clinical evidence suggests that semaglutide and bupropion do not have a major direct pharmacokinetic interaction