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Genetic variants in antioxidant enzyme genes (glutathione synthase, GPX, SOD) influence cellular glutathione production capacity

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The only molecules that can passively diffuse across the BBB are gases such as oxygen and carbon dioxide, and small lipid-soluble molecules with a molecular weight under 400 Da or containing less than 8 hydrogen bonds (e.g., ethanol, antidepressants) [17]

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