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The immunomodulatory component of ASHMI that regulates IL-5 and IL-10 production by PBMCs from asthmatic patients were assessed ex vivo , whereby Sophora flacescens fraction 2 (SF-F2) that is alkaloid rich was more effective at increasing IL-10 and fraction 4 (SF-F4) was more effective at decreasing IL-5 [107]

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