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Tissue remodelling does involve breakdown before rebuilding

NSAIDs inhibit COX enzymes, decrease prostaglandin production, and thus reduce peripheral and central sensitization to pain (280)

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Potential of exosomes for diagnosis and treatment of joint disease: towards a point-of-care therapy for osteoarthritis of the knee. International journal of molecular sciences 22.5 (2021): 2666

In this scenario, with some sacrifice on warhead reactivity (k inact ), a high overall efficacy (k eff ) can only be achieved through optimizing for the non-covalent binding contribution (reflected by inactivation constant K I ) [107]