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228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable targetincreased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels

It is synthesized and secreted from the intestinal enteroendocrine L-cells (located in the distal ileum and colon) after meals in response to caloric intake

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