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Specifically, total hepatic CE content in KO mice was 40% lower than in WT mice fed regular chow diet

Peptide hormones, growth factors, related substances, and mimetics, S4

Similar to other peptide-bound GLP-1R structures 13, 16 , exendin-4 and oxyntomodulin adopted a continuous alpha helix, with their C-terminus bound within the ECD and their N-terminus bound deep within the TMD forming extensive interactions with residues within TM1, TM2, TM3 TM5, TM6, TM7 and ECL2 (Figures 1-2, Supplemental Figure 4)