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Simultaneously, the GLP-1 receptors are stimulated to decrease glucagon secretion, slow gastric emptying, and decrease appetite

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In fact, 91% of trial participants maintained their weight loss through the full 48-week study without regain

Diarrhea, vomiting, and constipation : Common across both medications during the titration period

While the study concluded that short-term DSIP treatment was unlikely to be of major therapeutic benefit noting that statistically significant effects were weak and partly attributable to incidental placebo group change it provided the most methodologically rigorous human sleep architecture dataset for DSIP and confirmed the compounds specific effect on objective, not merely subjective, sleep quality parameters