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6-10,19 Since tirzepatide is known to cause GI adverse effects, dehydration is a possible outcome and can subsequently cause acute kidney injury

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doi: 10.1152/ajpendo.00578.2013

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In preclinical models, female mice showed greater increases in muscle mass in response to MSTN blockade, whereas male mice demonstrated more prominent reductions in fat mass.[58] However, clinical evidence for sex-based differences in patient outcomes remains limited, partly because most clinical studies have focused on assessing the safety of the drug in postmenopausal women or have primarily targeted elderly individuals with sarcopenia