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Animal studies have also shown that portal vein GLP-1 weakens intestinal fat absorption and chylomicron production through the vagal enteric-brain-liver axis, and reduces postprandish and fasting blood lipids [79]

Additives can alter pharmacokinetics, potentially impacting the efficacy of the active molecule

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Furthermore, it has been reported that the administration of exenatide attenuates the renal inflammation index, including reducing the TNF-, IL-6, hsCRP, and CCL5 levels, in STZ-induced diabetic rats by increasing the superoxide dismutase and decreasing malondialdehyde levels (Wang et al., 2019)

Blood pressure reductions emerge within weeks to months