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This explains why lean, physically inactive patients can present with significant insulin resistance, and is one reason mitochondria-targeted peptides have drawn serious research attention

Mol Cell Biol 30:45074520 Ni L, Zheng Y, Hara M, Pan D, Luo X (2015) Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling

Of note, ferroptosis likely contributes to unbalanced myeloid/lymphoid lineage differentiation of long-term HSCs via cholesterol-mediated promotion of ferroptosis resistance in a SLC38A9mTOR axis-dependent fashion in a murine model of hypercholesterolemia

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Pre-specified outcomes The primary outcome was defined as the annual rate of acute healthcare utilization (number of events per year of follow-up): calculated as the sum of urgent care visits, Emergency Department visits, and hospitalizations divided by the duration of follow-up