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The main mechanism is activation of type I and III collagen synthesis (up to +70% according to Pickart 2018), elastin (+40%) and glycosaminoglycans, including hyaluronic acid (+60%)
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In a pilot study in Thailand, Sangsuwan and Asawanonda tested the influence of daily intake of oral collagen (5 g) for 4 weeks on skin elasticity, especially in sun-exposed areas, in a randomized, double-blind, placebo-controlled trial (in a total of 36 women, aged 4060 years, where one-half of the participants were in the treatment group [ n = 18] or the placebo group [ n = 18]) [39]
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Treatment protocols are typically individualized based on health goals and clinical guidance
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