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Accordingly, rebound in the periconception period should be viewed as a clinically plausible translational concern rather than as a phenomenon established specifically in women with PCOS

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The naturally occurring endocannabinoid anandamide also caused similar 24 h loss of cell viability in developing mouse cortical neurons at concentrations ranging from 1 to 100 mcg/mL, indicating the mechanism of cell death could be mediated through the cannabinoid receptors

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