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Western blot profiling showed a modest but sustained increase in phosphorylation of S6 kinase and its target S6 with 5FU treatment over time (Fig

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The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo. 2005 Anderson, J., et al

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The peak phase is often less intense but longer, lasting up to two weeks