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Jaundice and hepatic enzyme elevations (mostly consistent with cholestasis or hepatitis), in some cases severe enough to require hospitalization, have been reported in association with use of amlodipine

Recent studies suggest that GLP-1R agonists may influence the neurovascular unit (NVU), the critical interface where neurons, glial cells, and blood vessels interact to maintain brain function

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These enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative damage

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