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Since mitochondria are essential to our very existence, it is unsurprising that the effects of mitochondrial diseases can be severe, and sometimes lethal, spanning a wide-ranging spectrum of physiological and biochemical symptoms [1,3,4] (see Table 1 for examples)

Some of these molecules have also entered clinical trials and we will possibly welcome in the future the approval of a GST inhibitor or pro-drug for the treatment of patients

525 Age-dependent changes of astrocytic morphology have been understudied, with some controversial observations reported when only the morphology of GFAP-stained profiles was analysed, which can easily be misinterpreted

Nguyen and Soulika, 2019)

Zhang et al., 2005