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Objective criteria for diagnosis of clinical obesity and pre-obesity exist 5 , which provide a framework for clinical decision-making and prioritization of therapeutic interventions (Figure 1)

Furthermore, the oxidative stress in patients with T2DM can be ameliorated by multispecies probiotics (222)

These protective effects are thought to involve the MGBA, including modulation of the glucagon-like peptide-1 (GLP-1) receptor pathway, which influences both brain and metabolic health (Sun et al., 2019a)