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It works on both the GIP and GLP-1 receptor pathways, which is why many patients group it with GLP-1 weight-loss injections

The treatment-regimen estimand with weight management represents the estimated average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments

23 The recent wave of state Medicaid agencies withdrawing or restricting coverage for AOMs, particularly GLP-1s, reflects a unique tension between groundbreaking clinical efficacy, rapid uptake, optional coverage, and immediate fiscal reality

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the long-term financial benefits are also noteworthy