retatrutide benefits besides weight loss vs. Tirzepatide: The New Contender vs. the Current Leader Retatrutide for Weight Loss: TRIUMPH-1

Departments of Agriculture and Health and Human Services | AAFP, accessed April 22, 2025, Healthy diet - World Health Organization (WHO), accessed April 22, 2025, 2015-2020 Dietary Guidelines for Americans - Office of the Assistant Secretary for Health, accessed April 22, 2025, Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss

Reads for annotated (Ensembl) genes were counted using HtSeq

If these medications get too warm for too long, they can lose effectiveness

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SURPASS-2: The Only Head-to-Head Trial The SURPASS-2 trial (NEJM, 2021) is the most important study in this comparison because it directly tested tirzepatide against semaglutide in 1,879 patients with type 2 diabetes over 40 weeks