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Semaglutide is a breakthrough medication belonging to a class of drugs known as GLP-1 (Glucagon-Like Peptide-1) receptor agonists

People used to think that weight loss was just a matter of will power

In vitro BBB models are widely used to study BBB physiology and the cellular mechanisms involved in this barrier as it can be readily manipulated

However, if the cells are sent when the body doesnt need them, this may spur chronic inflammation, which is known to be a symptom of several diseases, including Alzheimers

More GLP-1 was needed to achieve the same biological effect, indicating the participants were GLP-1-resistant