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On the other hand, it is not clear whether FasL induces the formation of this complex, since it was reported that its activation was ROS-dependent and ligand-independent due to the inability of Fas agonists to activate caspase-8 and trigger cell membrane scrambling in mature RBCs [192]

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Therefore, the development of this vaccine in clinical trials could be more complicated than in in vivo experiment, given the diverse physiological functions of GPNMB in normal cells

The proteins are presented in order of significance

10.1053/j.gastro.2009.08.042 Gastroenterology