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During World War II due to challenges accessing quina tree groves, quinacrine was synthesized, followed by chloroquine in 1934 and then HCQ in 1946, considered a safer alternative to chloroquine

Stopping supplementation when symptoms improve allows the deficit to rebuild, creating fatigue recurrence within 35 days

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doi: 10.2337/dc07-0589 104 ThompsonRGPearsonLSchoenfeldSLKoltermanOG

Pegylated arginase PEG-BCT-100 combined with oxaliplatin and capecitabine has shown satisfactory therapeutic efficacy and safety in phase I clinical trials in solid tumors