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This improved comfort may be related to: More balanced hormonal signaling (GLP-1 + GIP) GIP activity that may reduce GLP-1-related nausea Smoother appetite regulation at equivalent weight-loss levels Personalized dosing and slow titration are essential for both medications

Implications in the United States: Compounded Versions: During the shortage, compounding pharmacies produced semaglutide versions to meet demand

Bostom et al, 1997

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