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The anti-apoptotic gene bcl- 2 is a promoter of transcription in the nucleus by a complex between CREB and TORC2

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This provides an explanation for the involvement of neurexins proteins in the mechanism of sustained antidepressant effect mediated by BDNF signaling, but recent studies have not clarified their relative upstream and downstream relationship to BDNF signaling, and the mechanism of this regulation at the protein level awaits further clarification

Front Cell Dev Biol 3:4 Horikawa N et al (2017) Expression of vascular endothelial growth factor in ovarian cancer inhibits tumor immunity through the accumulation of myeloid-derived suppressor cells

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