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In particular, under hypoxic conditions, Gln consumption is elevated, and Gln carbon is mainly used for fatty acid production through the reductive carboxylation of KG and citrate synthesis [83,84,85], whereas the Gln-derived nitrogen is expelled from cells in the form of dihydroorotate to prevent ammonia-induced toxicity [85]

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Semaglutide and tirzepatide produce substantially more weight loss than liraglutide, as reported in both RCTs and realworld data

According to the FDAs database, the number of adverse events reported for each semaglutide drug since they have been released up until June 30, 2023, are as follows

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