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and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)

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Any change in status requires notice-and-comment rulemaking, commonly 8 to 12 months, with no assurance of completion

Consequently, a comprehensive and systematic understanding of the specific molecular regulatory mechanisms of mitochondrial quality control using novel technologies and methodologies is a pivotal objective of future research (Figure 4)