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Adipose Tissue Immunomodulation As previously discussed in Chapter 2, exposure to obesogenic compounds, mainly plasticisers, was demonstrated to dysregulate the secretion of a panoply of cyto/chemokines by adipose tissue, which includes the upregulation of proinflammatory mediators linked to the prostate carcinogenic process, namely several ILs (IL-1, 6, 8, 17A, 18), TNF-, MCP-1 and CCL20 [174, 175, 177, 178, 203]

In the Look Action for Health in Diabetes study, where overweight and obese patients with T2D were treated with intensive lifestyle intervention, patients had a mean weight loss of 8.6% after 1-year

They're the molecules that neutralize harmful free radicals that cause damage to our cells, which in turn, can manifest as life-threatening issues like cancer, stroke, heart disease, and other age-related diseases

primary tumors build biomass such as glucose to sustain their high proliferative demands

This makes the skin look darker and feel thicker than normal skin