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Warning: If pregnant or nursing, consult your healthcare

Creatine does not cause long-term water retention, or dehydration for that matter (a common trope that is seemingly at odds with itself)

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The cAMP/PKA pathway inhibits voltage-gated potassium channels that respond to depolarization, opens and allows K + efflux, repolarizing the cell and allowing increased calcium influx through voltage-dependent calcium channels, resulting in the exocytosis of insulin from -cells (115)

Hence, it is imperative for both patients and physicians to prioritize the management and control of relevant risk factors in clinical practice