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The mean changes in SBP, DBP, HbA1c and body weight from baseline were used as investigated parameters, expressed as WMDs and corresponding 95% CIs

This physiological shift often results in pronounced metabolic dysregulation, including increased adiposity, insulin resistance, and impaired glucose tolerance [146]

DOI: 10.1016/j.cmet.2025.07.004 This study was supported by the National Institutes of Health, including the National Institute of Diabetes and Digestive and Kidney Diseases (grant numbers DK107397 and DK127979), the National Institute of General Medical Sciences (grant number GM144613), the National Institute on Aging (grant numbers AG074535, AG065993, AG076075, and AG086328), and the National Cancer Institute (grant number CA286584), as well as by the Grant-in-aid for Japan Society for Promotion of Science Fellows (grant number 24KJ2039)

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