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This is crucial for understanding the proteoform concept (Smith et al., 2013) highlighting the idea that the complexity of biological systems is not solely dictated by their genome size, but rather by the vast and functionally diverse proteome, consisting of a multitude of unique proteoforms derived from a relatively small number of genes (Schluter et al., 2009)

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The peptide's actin-sequestering activity proves particularly important for endothelial cell migration, with studies showing TB-500 significantly enhances endothelial cell migration rates and tube formation in angiogenesis assays while promoting the formation of stable, mature blood vessels with appropriate pericyte coverage

Additionally, Cbl deficiency has been associated with decreased immune function, such as reduced CD8 T cells and natural killer cells [29]

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