Here are the behavioral and physiological reasons why you might gain weight after stopping semaglutide: While weight regain can happen after stopping semaglutide, the best strategies include lifestyle habits involving nutrition and physical activity, as well as ongoing support and planning with your medical provider
doi: 10.1016/S0140-6736(25)01674-5 72 PescovitzMDGreenbaumCJKrause-SteinraufHBeckerDJGitelmanSEGolandRet al
Ingredients, dosages and effectiveness in them can vary widely depending on the brand
Elevated cortisol promotes fat storage, increases insulin resistance, and stimulates appetite through pathways that partially bypass GLP-1 signaling
If pharmaceutical companies or researchers wanted to move this idea forward, it would require showing that leptin is adding a benefit on top of GLP-1s, said Jens Holst, a professor of physiology at the University of Copenhagen