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AP can be characterized by two temporal phases, early or late, with degrees of severity ranging from mild (no organ failure) to moderate (organ failure less than 48 hours) to severe (persistent organ failure has occurred for more than 48 hours)

Romeo S, Sentinelli F, Dash S et al (2010) Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

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The second cause of leptin resistance is impaired leptin signal transduction in neurons, including SOCS3, PTP1B