A lower DAR value may reduce the anti-tumor efficacy, while a higher DAR may affect the structure, stability, and antigen binding ability of the antibody, thereby leading to loss of activity
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J Biol Chem 286(30):2651626523 Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Spiegelman BM (2010) Transcriptional control of preadipocyte determination by Zfp423