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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

Thats where it gets murky

When intake falls short or absorption fails, supplementation or injections can help restore healthy levels

With B12 injections, all the dose is delivered into the bloodstream, so you get the maximum benefit

The glucagon receptor component does not appear to cause significant glucose-raising effects in the context of GLP-1 co-activation, suggesting that the three receptor pathways balance each other in important ways