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Septic cardiomyopathy (SIC) In a model of LPS-mediated septic cardiomyopathy, some researchers revealed that LPS caused ferroptosis and septic cardiac injury by downregulating GPX4 protein levels and increasing COX-2 [93]

However, for the majority of proteins these reactions could occur only under non-physiological GSH/GSSG ratio (i.e., 1:1)

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