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Importantly, these findings were later corroborated by in vivo studies where both acute (single high-dose striatal injection) and sub-chronic (21 days of 30 mg/kg intranasal Mn) exposure reduced GLAST/GLT-1 expression and were associated with motor deficits, at doses approximating human Mn exposure (Johnson et al., 2018

References Zhou BB, Zhang H, Damelin M, Geles KG, Grindley JC, Dirks PB

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Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement

Instruct patients to inform healthcare providers prior to any planned surgeries or procedures if they are taking WEGOVY [see Warnings and Precautions (5.11)]