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A., Dias, M

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Yes, we advise against it

These alterations suggest impaired mitochondrial bioenergetics, consistent with previous reports showing reduced mitochondrial activity and altered lipid metabolism in lipedema adipose tissue [57, 58]

Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)